Alzheimer’sDisease相关论文
Behavior deficits and region specific alterations in local field potential oscillations in APP/PS1 m
Alzheimers disease(AD)is the leading cause of dementia,estimated to affect more than 30 million individuals worldwide....
Objective Alzheimers disease(AD)is the most common form of dementia in elderly people....
Early,reliable and non-invasive diagnosis of Alzheimer disease(AD)is a great challenge,which makes the prognosis and the......
DNA methylation has been reported to be involved in Alzheimers disease(AD),a common neurodegenerative disorder in the el......
APP but not Aβ is the major factor affecting adult hippocampal neurogeneis in an animal model of Alz
New neurons are generated continuously in the dentate gyrus(DG)of hippocampus throughout adulthood in rodents and most o......
Brain derived neurotrophic factor(BDNF)has been known to play an important role in various mental disorders or diseases ......
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ productio
Accumulation of β-amyloid(Aβ)peptide is critical for the pathogenesis of Alzheimers disease.Generation of Aβ involves......
MicroRNA-132 and early growth response-1in Nucleus Basalis of Meynert during the course of Alzheimer
The cholinergic Nucleus Basalis of Meynert(NBM),which is important for memory functions,shows neuronal activation(up-pha......
Objective Alzheimers disease(AD)is characterized by the progressive decline of cognitive function among the elderly....
Objective Alzheimers disease(AD)is the most common type of dementia,which seriously affects the life quality of the elde......
Objective Alzheimer disease(AD)is a fatal neurodegenerative disorder characterized by progressive cognitive impairment a......
Alzheimers disease(AD)is a degenerative disorder of the central nervous system,which often impairs learning and memory,e......
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Beta-amyloid(Aβ)cascade theory is the most recognized pathogenesis of Alzheimers disease(AD)....
Alzheimers disease(AD)is an age-related neurodegenerative disorder,and characterized by chronic progressive deterioratio......
Alzheimers disease is a progressive neurodegenerative disorder in the presenium and geratic period,which is characterize......
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Its accepted that amyloid β-derived diffusible ligands(ADDLs)play a prominent role in triggering the early cognitive de......
Alzheimers disease(AD),the most common cause of dementia among neurodegenerative diseases in the elderly population,is c......
Simultaneous determination of eight bioactive components of Kai-Xin-San in rat plasma by UFLC-MS/MS:
A rapid,sensitive and reliable ultra-fast liquid chromatography with tandem mass spectrometry(UFLC-MS/MS)method was deve......
Policy and Practices Updates Future research on dementia relating to culturally and linguistically d
About one in five older Australians were born overseas.However,there has been very little information published in Austr......
本试验通过对自然衰老大鼠进行行为学筛选得到拟老年性痴呆（Alzheimer’s disease，AD）模型大鼠，灌胃给予NWK12 周。通过Morris 水迷宫......
ROI based pathological changes detection of Alzheimer’s disease using SVM-RFE: A study of DKI and DT
Diffusion kurtosis imaging(DKI)is a simple extension of the diffusion tensor imaging(DTI)technique and widely used in cl......
阿尔茨海默症(Alzheimer′s disease, AD)的药物疗效欠佳, 单色光照射治疗是候选方案之一。本文综述了开展的单色光治疗AD的细胞模......
Frequency-specific Alterations of Large-scale Functional Brain Networks in Patients with Alzheimer’s
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目的初步了解重组人tau441 (P301S)蛋白体外聚集、抗原性及免疫原性等生物学性质。方法原核表达带His标签的tau441 (P301S)重组质......
Hippocampus Proteins Quantification and Interaction Analysis of Transgenic Mouse Encoded with Double
We hypothesize that the study of the global protein changes that occur in very specific regions of the brain will provid......
Dysregulation of iron homeostasis is involved in the pathological process of Alzheimer’s disease (AD).We have recently ......
Objective: The present study was designed to investigate the neuroprotective potential of lycopene on inflammatory r......
目的探讨高压氧(HBO)对阿尔茨海默病(AD)模型大鼠认知功能及海马组织中脑源性神经营养因子(BDNF)、酪氨酸激酶受体B(TrkB)、神经生......
Alzheimer’s disease(AD) is a progressive neurodegenerative disorder and one of the most common causes of dementia in th......
Early active immunization with Aβ3–10-KLH vaccine reduces tau phosphorylation in the hippocampus and
Active and passive anti-Aβ immunotherapies have successfully been used for the prevention and treatment of Alzheimer’s......
20S proteasome and glyoxalase 1 activities decrease in erythrocytes derived from Alzheimer’s disease
As a result of accumulating methylglyoxal and advanced glycation end products in the brains of patients with Alzheimer’......
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common form of de-mentia worldwide. A......
Given the failure to develop disease-modifying therapies for Alzheimer’s disease (AD), strategies aiming at preventing ......
A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against ce
Multiple lines of evidence show that soluble oligomer forms of amyloid β protein (Aβ42) are the most neuro-toxic speci......
目的:对金钗石斛叶中总黄酮进行提取分离,并考察其体外抗阿尔茨海默病(AD)活性.方法:采用超声提取法提取金钗石斛叶中总黄酮,将所......
目的 探讨嗅成鞘细胞(OECs)提取液脑室内注射对大鼠阿尔茨海默病的治疗作用.方法 SD大鼠双侧海马注射Aβ1-40,建立AD大鼠模型.实验......
目的 观察淫羊藿黄酮对β-淀粉样肽(Aβ)拟阿尔茨海默病(AD)模型小鼠学习记忆能力的影响.方法 将ICR小鼠随机分为正常组、假手术组......
目的 观察当归芍药散(DSS)对快速老化小鼠空间学习记忆能力的影响,为当归芍药散治疗阿尔采默病提供实验依据.方法 选用雌性SAM-P8......
目的 探讨丙戊酸钠(VPA)对不同性别APP/PS1双重转基因阿尔茨海默病(AD)模型小鼠的空间学习记忆能力及脑内老年斑(SP)的沉积的影响.......
目的探讨在体诱导大鼠海马CA1区长时程压抑(LTD)的诱导条件以及淀粉样β蛋白(Aβ)对其影响。方法给予大鼠海马CA1区Schaffer侧枝测......
